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CAS:57935-65-6,10-Demethoxy Nicergoline

时间: 2025-01-20 点击数:
产品名称:10-Demethoxy Nicergoline
产品别名:8β-(5-Bromonicotinoyloxymethyl)-1,6-dimethyl-10α-ergoline; Ergoline-8-methanol Indolo[4,3-fg]quinoline Derivative; Nicergoline EP Impurity G;
Impurity:Nicergoline EP Impurity G
CAS:57935-65-6
分子式:C₂₃H₂₄BrN₃O₂
分子量:454.36
产品类别:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用:10-Demethoxy Nicergoline is an impurity of Nicergoline (N394550) which is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
参考文献:Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)
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